Oxidative Stress Explained
Oxidative stress is like a tug-of-war happening inside your body between two forces: free radicals and antioxidants.
Free radicals are unstable little molecules your body naturally produces— especially when you’re turning food into energy or exposed to things like pollution, sunlight, or chemicals.
Think of them as tiny troublemakers. In small amounts, they’re part of normal life. But when they build up too much, they can start to damage your cells, your DNA, and the protective walls around your cells.
Antioxidants are the good guys, your body’s built-in defense team. They stabilize those free radicals, calming them down and preventing damage. You get antioxidants from your body’s natural processes and from colorful fruits, vegetables, herbs, and nuts.
When the free radicals outnumber the antioxidants, oxidative stress takes over. That’s when the damage can start — from premature aging to inflammation and long-term health issues. The great news? You can support this balance with healthy food, lifestyle choices, and personalized strategies based on your DNA.
Why Does Oxidative Stress Happen in the Body?
Oxidative stress happens when your body produces more free radicals than it can handle, and there aren’t enough antioxidants to keep them in check. While your body is designed to manage some oxidative stress daily, chronic exposure can overwhelm your natural defense systems.
Here are some of the most common reasons oxidative stress builds up:
Environmental Exposures
Breathing in pollution, cigarette smoke, mold, pesticides, or even synthetic fragrances can overload your system with toxins. These trigger free radical production and push your antioxidant defenses into overdrive.
Dietary Factors
Eating a diet high in processed foods, fried items, or excess sugar (and low in colorful fruits and veggies) deprives your body of the antioxidants it needs to fight off daily oxidative damage.
Lifestyle Choices
A sedentary lifestyle or pushing your body too hard with over-exercising can increase oxidative stress. Add in poor sleep or chronic stress, and your system may start to break down faster than it can repair.
Health Conditions
Chronic inflammation, autoimmune issues, or frequent infections can create a constant state of “internal stress,” which generates more free radicals and drains your resources for recovery.
Genetic Variations
Here’s where it gets personal. Some people are genetically more prone to oxidative stress. If you have variations in genes like SOD2, GSTP1, NQO1, or PON1, your body may not produce or recycle antioxidants as efficiently. Meaning you may need extra support through food, supplements, and lifestyle.
Which Genes Does SNiP Nutrigenomics Test That Provide Insights Into Oxidative Stress?
SNiP Nutrigenomics tests and formulates to support several genes that play a big role in how your body handles oxidative stress — the wear and tear caused by things like pollution, inflammation, stress, and even normal metabolism. Understanding your unique genetic blueprint in this area can help you better support your body’s natural detox and repair systems, especially when life gets overwhelming.
SOD2 (Superoxide Dismutase 2)
This gene helps produce one of your body’s frontline antioxidant enzymes, working deep inside the mitochondria (your cellular energy centers) to neutralize harmful byproducts. If your SOD2 variant isn’t as efficient, it may mean your cells are more sensitive to stress from toxins, chemicals, or even intense exercise. Supporting this gene can help protect your energy levels, skin, and aging process.
GSTP1 (Glutathione S-Transferase P1)
GSTP1 supports your ability to detox and defend against environmental toxins. It works by pairing glutathione (your master antioxidant) with harmful compounds to make them easier to eliminate. Variants in this gene can mean your detox pathways need a little more support from nutrition and lifestyle — especially when it comes to handling chemicals in food, skincare, or the environment.
NQO1 (NAD(P)H Quinone Dehydrogenase 1)
Think of NQO1 as part of your body’s recycling crew for reactive molecules that can cause cellular damage. It helps turn unstable compounds into safer forms, supporting cellular resilience and antioxidant capacity. Some gene variants may slow this process down, making it extra important to support your body with antioxidant-rich foods and nutrients.
PON1 (Paraoxonase 1)
This gene helps protect fats in your body — especially those in your blood and brain — from becoming damaged by oxidative stress. It’s also vital for breaking down toxic chemicals, like pesticides (organophosphates), that can build up in the body. If your PON1 function is less efficient, your system might need more help processing everyday exposures.
By exploring these genes, SNiP Nutrigenomics gives you a personalized snapshot of how your body responds to stress, toxins, and daily demands. With this insight, you can fine-tune your nutrition, supplements, and lifestyle choices to strengthen your antioxidant defenses and feel your best — from the inside out.
How Can CODE Complex ™ Support Your Body’s Defense Against Oxidative Stress?
The CODE Complex ™ is thoughtfully formulated with ingredients that help your body stay resilient in the face of oxidative stress — the internal “rusting” process caused by things like toxins, stress, poor sleep, and everyday metabolism. CODE Complex ™ helps you restore balance, energy, and cellular protection by supporting your antioxidant defense systems at the genetic level. Let’s take a closer look at how each blend works:
Proprietary SOD2 Blend
This blend is designed to support your body’s natural production of Superoxide Dismutase 2, an essential enzyme that helps neutralize damaging free radicals in your mitochondria (your cells’ energy centers).
Spirulina, Green Tea Extract, and White Tea Extract are rich in antioxidants like catechins and polyphenols, which help reduce oxidative stress and inflammation. These nutrients support healthy aging, energy, and immune function.
Organic Bilberry Extract adds extra antioxidant power with anthocyanins, plant compounds known to protect against cellular damage and support vision and vascular health.
Proprietary GSTP1 Blend
This blend targets your body’s glutathione system — often called the “master antioxidant” pathway. When GSTP1 gene function is compromised, your body may struggle to eliminate toxins efficiently.
Quercetin and Resveratrol are powerful plant-based compounds that help recycle and activate glutathione, boosting your detox capacity and calming inflammation.
Broccoli Powder is a natural source of sulforaphane, a compound that activates detoxification genes and supports the elimination of environmental toxins.
Proprietary NQO1 Supplementation
NQO1 plays a key role in reducing reactive compounds that cause oxidative damage. The ingredients here help reinforce this critical detox and energy pathway.
Coenzyme Q10 is included in both its traditional (ubiquinone) and highly bioavailable (ubiquinol) forms. This nutrient is essential for mitochondrial energy production and protects cells from oxidative stress, especially in the heart, brain, and muscles.
Proprietary PON1 Blend
PON1 is a gene that helps protect fats in your bloodstream and brain from oxidation. This blend helps keep those pathways functioning smoothly.
Reishi, Shiitake, and Maitake Mushrooms are not only immune-supporting adaptogens, they’re also rich in antioxidants that help reduce inflammation and oxidative damage.
Vitamin E, a fat-soluble antioxidant, helps protect cell membranes and keeps your lipid (fat) metabolism in balance — especially important for cardiovascular and brain health.
Additional Antioxidant Ingredients
Acerola Cherry (Vitamin C) provides immune and collagen support, helping combat oxidative damage at the cellular level.
Mixed Carotenes offer a spectrum of plant-based antioxidants that help neutralize free radicals and support healthy skin and vision.
Astaxanthin, a marine antioxidant, is especially powerful at reducing inflammation and supporting mitochondrial function.
Together, these ingredients work synergistically to support your body’s natural antioxidant systems based on your genetic blueprint. Whether you’re looking to support detoxification, energy, skin health, or healthy aging, the CODE Complex ™ offers targeted, science-backed support for a stronger, more resilient you.
What Other Body Systems Are Influenced by Oxidative Stress?
Oxidative stress doesn’t just affect one part of your body — it touches nearly every system, from your heart and hormones to your skin and mood. When your body can’t keep up with the free radicals caused by daily life, toxins, or inflammation, symptoms can show up in unexpected ways. Luckily, your DNA can offer valuable clues about where your system may need extra support.
Here’s how oxidative stress connects to different body systems — and how SNiP Nutrigenomics helps you understand your unique responses:
Cardiovascular System
Your heart and blood vessels are especially vulnerable to oxidative damage, which can affect their ability to transport nutrients, regulate blood pressure, and manage cholesterol.
PON1 gene helps protect fats in your bloodstream (like LDL cholesterol) from becoming oxidized — a key factor in long-term heart health.
GSTP1, a gene that supports detox and antioxidant defense, helps your body stay balanced under cardiovascular stress.
NQO1 gene strengthens your natural antioxidant systems, supporting heart resilience and helping reduce wear and tear on blood vessels.
Immune System
Your immune cells need a delicate balance — too little activity, and you’re prone to illness; too much, and you risk inflammation. Oxidative stress can tip this balance either way.
SOD2 (Superoxide Dismutase 2) gene helps clear oxidative byproducts inside immune cells, keeping them calm and focused.
IL6 (Interleukin-6) is a gene that influences your immune response to stress and inflammation; certain variants may lead to exaggerated immune activity.
GPX1 (Glutathione Peroxidase 1) gene supports glutathione function, a powerful antioxidant your immune system depends on for regulation and repair.
Nervous System
Your brain and nerves are highly sensitive to oxidative stress, which may manifest as mood swings, memory fog, or feeling “on edge.”
COMT (Catechol-O-Methyltransferase): This gene plays a key role in breaking down neurotransmitters like dopamine and estrogen, and this process depends on healthy methylation and oxidative balance.
SOD2, again, helps clean up oxidative stress within brain cells, keeping cognitive function and mood steady.
GSTP1, gene helps protect nerve cells from toxin-induced damage, supporting brain clarity and resilience.
Endocrine System
Your endocrine system controls hormones — from cortisol to estrogen — and oxidative stress can throw off that balance.
CYP11B2 (Cytochrome P450 Family 11 Subfamily B Member 2) plays a role in adrenal hormone production, affecting blood pressure and your body’s response to stress.
MTHFR (Methylenetetrahydrofolate Reductase) genes support methylation, which is key for detoxifying hormones like estrogen and supporting mood.
NQO1: gene assists with energy production at the mitochondrial level, which helps endocrine organs function smoothly.
Skin Health
Your skin is your largest detox organ and first line of defense against the environment. Oxidative stress can show up as premature aging, dullness, or inflammation.
SOD2 gene supports antioxidant defenses within skin cells, helping maintain firmness and clarity.
GSTP1 gene plays a role in detoxifying harmful compounds that your skin may be exposed to through air, water, or products.
VDR (Vitamin D Receptor) genes help regulate vitamin D activity, which is essential for skin repair, immune defense, and resilience.
Reproductive System
Hormonal balance and fertility are sensitive to inflammation and oxidative stress. These processes affect everything from menstrual cycles to egg and sperm quality.
The MTRR (Methionine Synthase Reductase) gene helps your body recycle B12 and support healthy methylation, which is vital for hormone production and cellular health in reproductive tissues.
COMT gene clears out estrogen and stress hormones, which helps balance mood, cycle regularity, and PMS symptoms.
GSTP1 gene supports detoxification in reproductive tissues, helping to reduce oxidative stress that may impact fertility and hormone metabolism.
Understanding these genetic factors can provide deeper insights into how your body manages oxidative challenges and supports overall wellness. SNiP Nutrigenomics testing highlights these unique genetic variations, and the targeted ingredients in CODE Complex ™ are designed to complement your body’s needs. With a combination of personalized insights and strategic support, you can take steps to help your body adapt and thrive in the face of oxidative challenges.
How to Reduce Oxidative Stress: Diet, Lifestyle, and Practices
Oxidative stress occurs when there’s an imbalance between free radicals and antioxidants in the body, which can lead to cellular damage. While the body has natural defenses to combat this, certain lifestyle and dietary choices can enhance your protection.
Boost Antioxidants with Your Diet
One of the most effective ways to combat oxidative stress is to include antioxidant-rich foods in your diet. Antioxidants neutralize free radicals, helping to protect cells from damage. Foods high in antioxidants include:
Berries: Blueberries, raspberries, and strawberries are packed with powerful antioxidants.
Leafy Greens: Vegetables like spinach and kale are excellent sources of nutrients that support cellular health.
Nuts and Seeds: Almonds, sunflower seeds, and other nuts/seeds are great for boosting antioxidant intake.
Citrus Fruits: Oranges, lemons, and other citrus fruits contain vitamin C, a key antioxidant.
Tomatoes: Rich in lycopene, an antioxidant that helps combat oxidative stress.
Cruciferous Vegetables: Broccoli, cauliflower, and similar veggies provide compounds that support the body’s detoxification processes.
Herbs and Spices: Ginger, turmeric, and other spices are potent sources of antioxidants and anti-inflammatory compounds.
Pro Tip: Include a variety of these foods to ensure you get a broad range of antioxidants and nutrients to support overall health.
Foods to Limit to Reduce Oxidative Stress
Certain foods can contribute to oxidative stress and should be consumed in moderation or avoided:
Processed Meats: Bacon, sausage, and deli meats are linked to higher risks of chronic diseases like heart disease.
Fried Foods: Cooking at high temperatures can produce harmful compounds.
Sugary Foods and Drinks: Excess sugar can trigger inflammation and oxidative stress.
Alcohol: Can damage cells and increase oxidative stress in the body.
Trans Fats: Found in processed and fried foods, trans fats can promote oxidative damage.
Recommendation: Focus on a balanced diet emphasizing whole foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats, while minimizing processed and fried foods, sugary drinks, and alcohol.
The Role of Lifestyle in Managing Oxidative Stress
A healthy lifestyle supports the body’s natural defenses against oxidative stress. In addition to diet, consider these strategies:
Regular Exercise: Moderate physical activity supports circulation and enhances the body’s antioxidant defenses.
Avoid Smoking: Smoking significantly increases oxidative stress and depletes antioxidant levels.
Stress Management: While yoga and meditation don’t directly reduce oxidative stress, they may help by lowering stress and anxiety, which are known contributors to oxidative damage. Improved circulation and overall well-being from these practices may also support the body’s defenses.
The Bigger Picture: Supporting Overall Well-Being
Reducing oxidative stress isn’t just about addressing free radicals—it’s about creating a lifestyle that supports your body’s resilience. A balanced diet, regular movement, stress management, and mindful choices can all contribute to reducing oxidative stress and promoting long-term health.
Focusing on these habits can strengthen your body’s natural defenses, protect your cells, and enhance your overall well-being.
Conclusion
Oxidative stress is a silent threat to your health, but with genetic insights from SNiP Nutrigenomics, you can understand your unique vulnerabilities and take proactive steps to address them. The tailored ingredients in CODE Complex ™ offer a comprehensive approach to fortifying your antioxidant defenses and supporting overall health. By reducing oxidative stress, you can positively influence numerous systems in the body, from heart health to hormonal balance, paving the way for optimal well-being.
Take Action: Know Your Genes and Unlock Your Health Potential
Discover your genetic blueprint and take control of your health with SNiP Nutrigenomics. By swabbing with us, you can unlock insights into all 103 genes we test, including those crucial for mold detoxification and overall well-being. Already have your DNA data? Enter your results to receive your customized nutrigenomics formulation, designed to optimize your detoxification pathways and empower your journey to better health. Take the first step today!
